Drug Discovery: High Throughput LC-MS/MS Analysis of Metabolic Stability Incubations

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Drug Discovery, Metabolism and Development eNews

Application note
Drug Discovery: High Throughput LC-MS/MS Analysis of Metabolic
Stability Incubations

High throughput screening (HTS) assays are commonly used in the
discovery stage of the drug development process where a large number
of compounds are screened. Compound optimization and sample analysis
are factors that limit throughput. This application note addresses
mass spectrometry optimization and sample analysis problems by using
the Thermo Scientific Aria TLX-4 multiplexed HPLC system, powered by
Thermo Scientific TurboFlow technology, and Thermo Scientific
QuickQuan software for the compound optimization process.

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